A . Pelc and Enrico Di Cera
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چکیده
10.1074/jbc.M113.451542 Access the most updated version of this article at doi: . JBC Affinity Sites Find articles, minireviews, Reflections and Classics on similar topics on the Alerts: When a correction for this article is posted • When this article is cited • to choose from all of JBC's e-mail alerts Click here http://www.jbc.org/content/288/16/11601.full.html#ref-list-1 This article cites 54 references, 13 of which can be accessed free at
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In addition to its procoagulant and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C receptor. Once in the circulation, activated protein C functions as an anticoagulant, anti-inflammatory and regenerative factor. He...
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OBJECTIVE Thrombin containing the mutations Trp215Ala and Glu217Ala (WE) selectively activates protein C and has potent antithrombotic effects in primates. The aim of this study was to delineate the molecular mechanism of direct WE-platelet interactions under static and shear conditions. METHODS AND RESULTS Purified platelets under static conditions bound and spread on immobilized wild-type b...
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Short Title: Hemostatic Safety of Protein C Activators Authors: András Gruber, Ulla M. Marzec, Leslie Bush, Enrico Di Cera, José A. Fernández, Michelle A. Berny, Erik I. Tucker, Owen J.T. McCarty, John H. Griffin, and Stephen R. Hanson Institutions: From the Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR; the Department of Biochemistry and Molecular Bioph...
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Prothrombin is the zymogen precursor of the clotting enzyme thrombin, which is generated by two sequential cleavages at R271 and R320 by the prothrombinase complex. The structure of prothrombin is currently unknown. Prethrombin-1 differs from prothrombin for the absence of 155 residues in the N-terminal domain and is composed of a single polypeptide chain containing fragment 2 (residues 156-271...
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